Molecular Link Between Voltage-Sensor Modification and Local Anesthetic Block
نویسندگان
چکیده
منابع مشابه
Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels.
Voltage-gated Na+ channels are the molecular targets of local anesthetics, class I antiarrhythmic drugs, and some anticonvulsants. These chemically diverse drugs inhibit Na+ channels with complex voltage- and frequency-dependent properties that reflect preferential drug binding to open and inactivated channel states. The site-directed mutations F1764A and Y1771A in transmembrane segment IVS6 of...
متن کاملMolecular modeling of local anesthetic drug binding by voltage-gated sodium channels.
Voltage-gated sodium (Na+) channels are targets for local anesthetic (LA) drugs that bind in the inner pore of the channel with affinities related to the channel gating states. Our core model of the sodium channel (P loops and S5 and S6 segments from each of the four domains) was closed because it was developed using coordinates from the KcsA channel crystallographic structure. We developed a m...
متن کاملvertical infraclavicular block with local anesthetic injections at different currents.
injecting local anesthetic at the seeking current would be appealing.it would save time and avoid potentially dangerous manipulations of the needle. this study aimed to test the hypotheses that in vertical infraclavicular block, injecting local anesthetic at a seeking current of 0.8 ma would produce the same quality of block as injecting at ≤0.5ma. a total of sixty asa i -iii adult patients sch...
متن کاملModification of local anesthetic-induced antinociception by fentanyl in rats.
In clinical practice, using the lowest doses of drugs for anesthesia or analgesia is the main goal. Opioid combinations with local anesthetics can be preferable for achieving adequate anesthesia or analgesia. The primary purpose of this study was to examine possible thermal antinociceptive effects of the opioid -fentanyl and the amide local anesthetics levobupivacaine and lidocaine when locally...
متن کاملVertical infraclavicular block with local anesthetic injections at different currents.
Injecting local anesthetic at the seeking current would be appealing.It would save time and avoid potentially dangerous manipulations of the needle. This study aimed to test the hypotheses that in vertical infraclavicular block, injecting local anesthetic at a seeking current of 0.8 mA would produce the same quality of block as injecting at ≤0.5mA. A total of sixty ASA I -III adult patients sch...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2010
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2009.12.4209